hello! i have astigmatism so im giving my thoughts here based on my own personal experiences and in association with having eyesight / vision problems!

for me, i prefer medium dark skins with high contrast but Not white on black and without neon / bright colors. it's easiest for me to read text (especially in paragraph form) on a dark grey background with clearly defined text. a lot of light skins are too bright for my eyes - though a light skin done with a dark background or dark accents is probably the absolute most accessible. ie - something in the middle, mostly. i struggle a lot with reading extreme contrast (white on black or black on white) and it really also depends on the colors used for the site.

i think it largely depends on the accent colors used in the skin. if its a dark skin with bright colors/neon colors, then it's probably a no for me. however, the same could be said for light skins with bright or neon colors as well. the lower the contrast of the accent color, the easier it for me because, like many other people, i also have an astigmatism, except i have them in both eyes. 

so bright colors tend to just not go over well, so 'duller' the accent, the easier it is for my eyes to process the sight i'm seeing. 

probably not helpful but light skins and dark skins are both good in my eyes. in the past though, i gravitated toward darker sights that used dull colors because i didn't like frying my retinas just to look at a site's skin. 

I believe I've said this before. I don't like dark skins, they make me really depressed and feel claustrophobic. So, if I can avoid them I will, but I have joined sites with dark skins before. I just try not to stay on them too long or those feelings crop up. I don't know if anyone else experiences those feelings. I don't really understand them myself. :<

Hmm...actually maybe I do. Where I live, we have lots of snow which makes the world seem very light and white, like a light skin, but in winter we lose the sun really fast, like by 3pm it's pitch black outside until the next day at around 11am type of thing.

So I guess, because of where I live in the world I equate light skins to something too look forward to, where as dark skins remind me of the depressing endless nights we experience 8-9 months where I live. Ha, who knew mystery solved for me. LOL sorry for hijacking this thread with my random deep thoughts of the day.