Been playing a lot of games and consuming a lot of other media that developed a jumbled but possible idea that can work out:
Set in the distant future, America's economy has crashed and suffered through another Great Depression.
In comes a major corporation called MIYAKI, based in Japan, that later brought the country to its economical peak to a point where it had no choice but to rely on these 3 corporations as means for survival. Since then, these MIYAKI became the new form of government. With such power, MIYAKI viewed America as the perfect testing site for their upcoming project:
Operation PRSRV (pronounced "preserve") is a project that had one goal: control the human race; with such a flawed species that have damned the world into sin with their free will, they must be controlled and create a controlled utopia where such harm to both the planet and its inhabitants. Those with an immense amount of wealth won't be subjected to the process.
This involved a virus created by MIYAKI called
Jackal that would spread in hopes of infecting the entire American population, only to infect just a faction of the population. Those infected were dubbed the same name as the virus. They were humanoids with traits related to animals, mythical beings, and legendary creatures; they also gained powers, creating different types of powered Jackals who can spread the virus, infecting humans into their own kind. To the MIYAKI's surprise, they had no control over the Jackals.
With no trace of evidence leading the virus to the corporation, the MIYAKI have created anti-Jackal propaganda and have officially labeled them as threats to not just the country, but to humans as a whole. This sparked racism, political strained relations, and oppression while the corporation continues to hide their trail.
There may be a second corporation involved that rivals against MIYAKI but with the same intentions in mind, but for now if there's enough interest I'll have no problem diving into detail.